Archives
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br Results br Discussion This work
2020-08-05
Results Discussion This work provides evidence of a functional role of T-UCEs in regulating the finely tuned balance between pluripotency and differentiation in mouse ESCs. So far, the T-UCEs have been mostly linked to cancer, whereas their physiological role is still poorly understood. Based
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br Biological functions For CcPDH
2020-08-04
Biological functions For CcPDH, the occurrence of the non-catalytic, cellulose binding domain indicates a role in plant cell wall degradation, a complex process carried out by the synergistic action of hydrolases and oxidoreductases []. Interestingly, CcPDH shows the highest oxidative activity to
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A series of monocarboxylated chalcones e g compounds
2020-08-04
A series of monocarboxylated chalcones (e.g. compounds 7 and 8, Fig. 2A) was previously identified as good CysLT1 antagonists [20], and none of them exhibited CysLT2 antagonistic activities (Supplementary Table S1). This study was consistent with reported result that CysLT2 ccr2 inhibitor was not se
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The COMT gene maps to chromosome q Grossman
2020-08-04
The COMT gene maps to chromosome 22q11.2 (Grossman et al., 1992) and has two protein isoforms. The differences between S-COMT and longer MB-COMT are in the N-termini, which use alternative translation initiation sites and promoters. These two isoforms display different affinity and capacity for COMT
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Replacement of the saturated propoxy group in compound with
2020-08-04
Replacement of the saturated -propoxy group in compound with the unsaturated allyloxy group to obtain compound resulted in 10-fold decrease in ET receptor antagonism and more than 20-fold decrease in ET-selectivity. Analogous unsaturated allyloxy compound in the tetrazole series was found to have
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1 25-dihydroxyvitamin d3 receptor Impulsive burying and free
2020-08-04
Impulsive burying and freezing behaviors in response to aversive stimuli may represent attempts to avoid novel and/or aversive stimuli. These behaviors can be assessed utilizing the marble burying and conditioned fear tasks, respectively. For example, Wistar rats in proestrus and ovariectomized rats
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br Methods br Results br Discussion The results
2020-08-04
Methods Results Discussion The results of this study show that 10µM PGE2 induces EP4 externalization from its previously characterized localization in the Golgi apparatus [23] to the plasma membrane in undifferentiated NE-4C stem cells. 1µM PGE2 did not have a significant effect on undiffer
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Although we observed increases in
2020-08-04
Although we observed increases in α1-AR mediated cAMP production separately in the nucleus and cytoplasm, compartment specificity was observed for PKA activation. GPCRs and their effector proteins are commonly found in multiprotein signalosomes with A-kinase anchoring proteins (AKAPs) serving as sca
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The histologic finding that EBV infected B cells in infectio
2020-08-04
The histologic finding that EBV-infected Heparin synthesis in infectious mononucleosis tend to avoid the GCs and instead accumulate under the epithelium of certain mucosal tissues34, 129 could be explained by the above-mentioned expression patterns of chemokine receptors on EBV-infected B cells. CX
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Concerns that DPP inhibitor can increase the risk of heart
2020-08-04
Concerns that DPP-4 inhibitor can increase the risk of Olcegepant synthesis failure have been reinforced by the results of nonrandomized studies carried out in the community. Post-marketing analyses by the Food and Drug Administration have suggested a disproportionate reporting of adverse heart fail
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Another important issue that requires clarification is the
2020-08-04
Another important issue that requires clarification is the contribution of TLS regulators to replication of undamaged DNA. TLS pols are certainly required for the synthesis across difficult-to-replicate DNA structures such as common fragile sites [4], but their participation in undamaged DNA replica
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The remainder of this paper is organized as
2020-08-03
The remainder of this paper is organized as follows: Section 2 provides background on previous research about SE for scientific software. Section 3 describes the research methodology used in this systematic literature review. Section 4 reports the scientists’ and software engineers’ claims about SE
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Although retention effects might stem from differences in bo
2020-08-03
Although retention effects might stem from differences in both consolidation and/or recall of extinction memory, prefrontal dopamine – and thereby COMT enzyme lp-pla2 inhibitor – might be particularly relevant for consolidation as indicated by studies on endogenous prefrontal dopamine release in ra
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In summary the association of CK to tubulin and
2020-08-03
In summary, the association of CK1δ to α-tubulin and various proteins involved in mitosis points to a role of CK1δ in regulating key aspects of cell division and mitotic progression and by performing Michaelis–Menten kinetics we identified α-tubulin as the preferred interaction partner of CK1 isofor
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NCT-502 australia ClC is not only a chloride ion channel but
2020-08-03
ClC-3 is not only a chloride ion channel but also a regulatory protein involved in the regulation of multiple signaling pathways. The PI3K/AKT/mTOR signaling pathway plays a crucial role in regulating cell growth, migration, invasion, and distant metastasis [13,14]. Although abnormal PI3K/AKT/mTOR a